Pulp Regeneration: A new therapeutic option in immature definitive teeth
DOI:
https://doi.org/10.14295/idonline.v17i65.3685Keywords:
Regeneration, Endodontics, Immature Tooth, RevascularizationAbstract
Permanent teeth with open apices present a great challenge in cleaning and shaping root canals; in addition, they have a high probability for the risk of fractures due to the presence of thin or weakened walls in the root portion. Thus, pulp regeneration has emerged as a promising alternative for the treatment of these teeth, in order to control the infection of the root canal system, using minimum action of endodontic instruments as well as the use of abundant irrigation during biomechanical preparation. This technique consists of inducing bleeding in the apical region to form a clot with undifferentiated cells that, associated with growth factors, are capable of inducing tissue repair and neoformation. Therefore, the present work aims to carry out a literature review on pulp regeneration therapy, highlighting its clinical applicability, advantages, disadvantages, and care protocols. For this purpose, bibliographic references indexed on sites such as Google academic, PubMed and Scielo were used. Research indicates that pulp tissue revitalization promotes root development and thickening in immature permanent teeth with pulp necrosis. It is concluded that, although the pulp regeneration technique does not have a protocol considered gold standard, when it is well indicated, it can bring very satisfactory results for the patient. However, further studies still need to be carried out to verify the effectiveness of this new therapeutic proposal.
Downloads
References
ALBUQUERQUE, Maria Tereza Pedrosa, et al. Pulp revascularization: an alternative treatment to the apexification of immature teeth. Revista Gaúcha de Odontologia, v. 62, n. 4, p. 401-410, 2014. DOI: https://doi.org/10.1590/1981-8637201400040000082673
ALCALDE, Murilo Priori et al. Revascularização pulpar: considerações técnicas e implicações clínicas. SALUSVITA, Bauru, v. 33, n. 3, p. 415-432, 2014.
ALY, M. M.; TAHA, S. E. E.; SAYED, M. A.; YOUSSEF, R.; OMAR, H. M. Clinical and
radiographic evaluation of Biodentine and Mineral Trioxide Aggregate in revascularization of non-vital immature permanent anterior teeth(randomized clinical study). Int J PaediatrDent., Inglaterra, v. 29, n. 4, p. 464-473, 2019. DOI: 10.1111/ipd.12474. DOI: https://doi.org/10.1111/ipd.12474
BANSAL, R. et al. Regenerative endodontics: a road less travelled. J Clin Diagn Res, v. 8, n. 10, p. 20-24, 2014. DOI: https://doi.org/10.7860/JCDR/2014/8257.5034
BEZ, Paul Louis Marie. Revascularização pulpar em dente definitivo imaturo. Dissertação (Mestrado em Medicina Dentária) – Instituto Universitário Egas Moniz, 2021.
BRONCKAERS, A. et al. Angiogenic properties of Human Dental Pulp Stem Cells.
Public Library of Science, 8(8), pp. 1-11, 2013.
CHALISSERRY EP, NAM SY, PARK SH, ANIL S. Therapeutic potential of dental stem cells. J Tissue Eng. 1 jan.
CHAN, Ekm; DESMEULES; CIELECKI, M.; DABBAGH; FERRAZ, Dos Santos B.;
Longitudinal Cohort Study of Regenerative Endodontic Treatment for Immature NecroticPermanent Teeth. J Endod, 2017.
CHEN, Y.P.; JOVANI-SANCHO, M.; SHETH, C. C. Is revascularization of immature permanent teeth an effective and reproducible technique? Dental Traumatology, 31(6), pp. 429–436, 2015. DOI: https://doi.org/10.1111/edt.12214
CORREIA, Tânia Raquel Oliveira. Revascularização pulpar. Dissertação (Mestrado em Medicina Dentária) -Instituto Universitário de Ciências da Saúde, Lisboa, 2018.
COQUEIRO, I. S. S. da. et al. Medicação intracanal: aplicação da pasta tri-antibiótica na terapia endodôntica. In: JORNADA ODONTOLÓGICA DA UNIVERSIDADE BRASIL, 10, v. 7, 2018, São Paulo. Anuais da X Jornada Odontológica da Universidade Brasil. São Paulo: Arc Health Invest, p. 84, 2018.
CUNHA, Neto da Coêlho J. de A.; PINTO; CUELLAR, Mrc; MARCUCCI, Mc.; SILVA, et al. Antibacterial Efficacy of Triple Antibiotic Medication With Macrogol (3Mix-MP), Traditional Triple Antibiotic Paste, Calcium Hydroxide, and Ethanol Extractof Propolis: An Intratubular Dentin Ex Vivo Confocal Laser Scanning Microscopic Study. Journal of Endodontics, 2021. DOI: https://doi.org/10.1016/j.joen.2021.07.014
DEMARCO, G. T. et al. Qual a aplicabilidade clinica das terapias regenerativas em odontologia? RGO Rer. Gauch. Odontol., Porto Velho, v. 65, n. 4, p. 359-367, 2017. DIGKA, A.; SAKKA, D.; LYROUDIA, K. Histological assessment of human regenerative endodontic procedures (REP) of immature permanent teeth with necrotic pulp/apical periodontitis: A systematic review. Australian Endodontic Journal. 2020.
DIÓGENES, A. et al. An update on clinical regenerative endodontics. Endod Topics, Oxford, v. 28, n 1, p. 2-23,2013. DOI: https://doi.org/10.1111/etp.12040
FALCÃO, Janaína Maria Santos; BARROS, Karolliny dos Santos T. de; BARBOSA, Antônio Vinícius Holanda. Revascularização pulpar em dente traumatizado: relato de caso clínico. Monografia (Graduação em Odontologia)- Faculdade Integrada de Pernambuco, 2018.
FOUAD, A.F.; NOSRAT. A. Pulp regeneration in previously infected root canal space. EndodTopics, Oxford, v. 28, n. 1, p. 24-27, 2013. DOI: https://doi.org/10.1111/etp.12039
GALLER, K. M.; KRASTL, G.; SIMON, S.; GORP G. V.; MESCHI, N.; VAHEDI, B., et al. European Society of Endodontology position statement: Revitalization procedures. International Endodontic Journal. 2016. DOI: https://doi.org/10.1111/iej.12629
GASPAR, Fernanda Nogueira. Revascularização pulpar. Dissertaçao (Mestrado em Medicina Dentaria) – Universidade Fernando Pessoa, Porto, 2017.
GRONTHOS, M. et al. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America, pp. 13625-13630, 2000. DOI: https://doi.org/10.1073/pnas.240309797
GUERRERO F, MENDOZA A, RIBAS D, ASPIAZU K. Apexification: A systematic review.J Conserv Dent. 2018. DOI: https://doi.org/10.4103/JCD.JCD_96_18
HADDAD, T. Revascularização Pulpar: revisão de literatura. 2019. 46 f. Monografia (Especialização em Endodontia) – Centro Universitário de Lavras UNILAVRAS, Lavras, 2019.
HARGREAVES, K. M; DIÓGENES, A; TEIXEIRA, F. Treatment Options: biological basics of regenerative endodontic procedures. J endod, v. 39, s. 3, p. 30-43, 2013. DOI: https://doi.org/10.1016/j.joen.2012.11.025
HE, L.; ZHONG, J.; GONG, Q.; KIM, S. G.; ZEICHNER, S. J.; XIANG, L., et al. Treatment of Necrotic Teeth by Apical Revascularization: Meta-analysis. Sci Rep. 24, 2017. DOI: https://doi.org/10.1038/s41598-017-14412-x
KIM, D. S. et al. Long-term follow-ups of revascularized immature necrotic teeth: three case reports. In J Oral Sci, v. 4, n 2, p. 109-113, 2012. DOI: https://doi.org/10.1038/ijos.2012.23
KAHLER, B.; MISTRY, S.; MOULE, A.; RINGSMUTH, A. K.; CASE, P.; THOMSON, A., et al. Revascularization outcomes: a prospective Analysis of 16 consecutive cases. J Endod, 2014. DOI: https://doi.org/10.1016/j.joen.2013.10.032
KOÇ, S.; DEL, Fabbro M. Does the Etiology of Pulp Necrosis Affect Regenerative Endodontic Treatment Outcomes? A Systematic Review and Meta-analyses. J Evid Based Dent Pract., 2020. DOI: https://doi.org/10.1016/j.jebdp.2020.101400
LAW AS. Considerations for Regeneration Procedures. Pediatric Dentistry, 2013. DOI: https://doi.org/10.1016/j.joen.2012.11.019
MAHAJAN, T.; KOCHHAR, R.; KUMARI, M. Apexification Using MTA: A Challenging Approach. IJSRP, 2020. DOI: https://doi.org/10.29322/IJSRP.10.02.2020.p9828
MALHOTRA, N.; MALA, K. Regenerative endodontics as a tissue engineering approach:past, current and future. Aust Endod, 2012. DOI: https://doi.org/10.1111/j.1747-4477.2012.00355.x
MARTIN, De Almeida; HENRY, M. A.; KHAING, Z. Z.; SCHMIDT, C. E.; TEIXEIRA, F. B.,et al. Concentration-dependent effect of sodium hypochlorite on stem cells of apical papilla survival and differentiation. J Endod, 2014. DOI: https://doi.org/10.1016/j.joen.2013.07.026
NAGATA, Juliana Yuri, et al. Traumatized immature teeth treated with 2 protocols of pulper vascularization. Journal of Endodontics, v.40, n.5, p. 606-612, 2014. DOI: https://doi.org/10.1016/j.joen.2014.01.032
NAMOUR, M.; THEYS, S. Pulp revascularization of immature permanent teeth: a review of the literature and a proposal of a new clinical protocol. The Scientific World Journal, 2014. DOI: https://doi.org/10.1155/2014/737503
NICOLOSO, G. F. et al. Pulp revascularization or apexification for the treatment of immature necrotic permanente teeth: systematic review and meta-analyses. J Clin Pediatr Dent, v. 43, n. 5, p. 305-313, 2019. DOI: https://doi.org/10.17796/1053-4625-43.5.1
PASSOS, C. R. Revascularização pulpar: 2017. 15 f. Dissertação (Mestrado em Medicina Dentária) – Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, Porto, 2017.
PRADO, M. C. et al. Recurrence of dental trauma and management of Pulp revascularized tooth: a case report. J Dent Health Oral Disord Ther, v. 9, n. 4, p. 304- 308, 2018. DOI: https://doi.org/10.15406/jdhodt.2018.09.00397
SOARES, Andrei Sachett; BITTENCOURT, Wagner Pichini. Revascularização pulpar: implicações clínicas. Monografia (Graduação em Odontologia) - Universidade Federal de Santa Maria, Santa Maria, 2016.
TEIXEIRA. M. A. Revascularização pulpar: 2013. 57 f. Dissertação (Mestrado em Endodontia) – Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, Porto, 2017.
ZHANG, J.; AN, Y.; GAO, L-N; ZHANG, Y-J.; JIN, Y.; CHEN, F-M. The effect of aging on thepluripotential capacity and regenerative potential of human periodontal ligament stem cells. Biomaterials, 2012. DOI: https://doi.org/10.1016/j.biomaterials.2012.06.032
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Maria Larisse Cabral Silva, Ana Beatriz Hermínia Ribeiro Ducati de Sampaio, Eliane Maria Gonçalves Moreira de Vasconcelos, Mario Francisco de Pasquali Leonardi, Cicero Lucas Gomes Ramalho
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Os autores detêm os direitos autorais sem restrições, devendo informar a publicação inicial nesta revista, em caso de nova publicação de algum trabalho.