Stimulation from Electromagnetic Waves in the Prefrontal Cortex of the Brain
DOI:
https://doi.org/10.14295/idonline.v19i79.4331Keywords:
prefrontal cortex, magnetic stimulation, neurotherapeutic interventionsAbstract
The prefrontal cortex plays an essential role in higher cognitive functions, such as decision-making, inhibitory control, attention, and emotional regulation. In recent years, stimulation techniques based on electromagnetic waves have been widely investigated as non-invasive strategies to modulate neuronal activity in this cortical region. From this perspective, methods such as transcranial magnetic stimulation and transcranial alternating or direct current stimulation use electromagnetic fields to promote changes in cortical excitability, enabling both temporary and long-lasting functional reorganizations. Thus, the general objective of this study is to identify the effects of electromagnetic wave stimulation on the prefrontal cortex, with an emphasis on its impacts on cognitive and behavioral processes, as well as its therapeutic potential in clinical and experimental settings. For the development of this study, a bibliographic research methodology was adopted, consisting of a literature review with the selection of studies published in national and international scientific databases, such as PubMed, Scopus, and Web of Science. In this regard, possible results indicate evidence that electromagnetic stimulation of the prefrontal cortex can enhance executive functions, attention, and working memory, in addition to showing promising effects in the treatment of disorders such as depression, anxiety, and attention deficit. Furthermore, the findings may contribute to the improvement of stimulation protocols and to the advancement of neurotherapeutic interventions grounded in non-invasive neuromodulation.
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References
ADEY, W. R. Biological effects of electromagnetic fields. Journal of Cellular Biochemistry, New York, v. 51, n. 4, p. 410–416, 1993.
AMERICAN PSYCHIATRIC ASSOCIATION (APA). The Practice of Electroconvulsive Therapy: Recommendations for Treatment, Training, and Privileging. 2. ed. Washington, DC, 2010.
BARKER, A. T.; JALINOUS, R.; FREESTON, I. L. Non-invasive magnetic stimulation of human motor cortex. The Lancet, London, v. 325, n. 8437, p. 1106–1107, 1985.
BASSETT, C. A. L. Pulsed electromagnetic fields: a new method to modify cell behavior in calcified and non-calcified tissues. Calcified Tissue International, v. 34, n. 1, p. 1–8, 1984.
BEAR, M. F.; CONNORS, B. W.; PARADISO, M. A. Neuroscience: exploring the brain. 4. ed. Philadelphia: Wolters Kluwer, 2020.
BERLIM, M. T.; VAN DEN EYNDE, F.; DASKALAKIS, Z. J. Clinically meaningful efficacy and acceptability of low-frequency repetitive transcranial magnetic stimulation for major depression: a meta-analysis. Neuropsychopharmacology, v. 38, n. 4, p. 543–551, 2013.
BESTMANN, S.; WALSH, V. Transcranial electrical stimulation. Current Biology, London, v. 27, n. 23, p. R1258–R1262, 2017.
BINDMAN, L. J.; LIPPOLD, O. C. J.; REDFEARN, J. W. T. The action of brief polarizing currents on the cerebral cortex of the rat (1) during current flow and (2) in the production of long-lasting after-effects. Journal of Physiology, London, v. 172, n. 3, p. 369–382, 1964.
BUSHBERG, J. T. et al. The Essential Physics of Medical Imaging. 3. ed. Philadelphia: Lippincott Williams & Wilkins, 2012.
CONFORTO, A. B. et al. Transcranial magnetic stimulation and cortical excitability. Arquivos de Neuro-Psiquiatria, São Paulo, v. 61, n. 1, p. 146–152, 2003.
EKHTIARI, H. et al. Transcranial electrical stimulation: applications, mechanisms and safety. Brain Stimulation, New York, v. 12, n. 1, p. 1–15, 2019.
GEORGE, M. S. et al. Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder. Archives of General Psychiatry, v. 67, n. 5, p. 507–516, 2010.
HALLIDAY, D.; RESNICK, R.; WALKER, J. Fundamentos de física: eletromagnetismo. 10. ed. Rio de Janeiro: LTC, 2016. v. 3.
HENDEE, W. R.; RITENOUR, E. R. Medical Imaging Physics. 4. ed. New York: Wiley-Liss, 2002.
ILMONIEMI, R. J.; KICIC, D. Methodology for combined TMS and EEG. Brain Topography, New York, v. 22, n. 4, p. 233–248, 2010.
ISKANDER, M. F. Electromagnetic fields and waves in biomedical engineering. Hoboken: Wiley-IEEE Press, 2013.
JACKSON, J. D. Classical electrodynamics. 3. ed. New York: Wiley, 1998.
KITCHEN, S.; BAZIN, S. Clayton’s Electrotherapy: Theory and Practice. 10. ed. London: Churchill Livingstone, 1996.
LEFAUCHEUR, J. P. et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clinical Neurophysiology, v. 131, n. 2, p. 474–528, 2020.
MARKOV, M. S. Pulsed electromagnetic field therapy: history, state of the art and future. The Environmentalist, v. 27, p. 465–475, 2007.
MAXWELL, J. C. A dynamical theory of the electromagnetic field. Philosophical Transactions of the Royal Society of London, London, v. 155, p. 459–512, 1865.
PAOLUCCI, T. et al. Electromagnetic field therapy: a rehabilitative perspective in the management of musculoskeletal pain – a systematic review. Journal of Rehabilitation Medicine, v. 52, p. 1–9, 2020.
PASCUAL-LEONE, A. et al. Transcranial magnetic stimulation and neuroplasticity. Neuropsychologia, Oxford, v. 37, n. 2, p. 207–217, 1999.
POLK, C.; POSTOW, E. Handbook of biological effects of electromagnetic fields. 2. ed. Boca Raton: CRC Press, 1996.
ROSA, M. A. et al. Estimulação magnética transcraniana: aspectos de segurança e efeitos adversos. Arquivos de Neuro-Psiquiatria, São Paulo, v. 62, n. 2, p. 294–301, 2004.
ROSSI, S. et al. Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clinical Neurophysiology, Amsterdam, v. 120, n. 12, p. 2008–2039, 2009.
ROSSINI, P. M. et al. Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves. Clinical Neurophysiology, Amsterdam, v. 126, n. 6, p. 1071–1107, 2015.
ROTH, Y. et al. A randomized controlled study of deep transcranial magnetic stimulation for treatment-resistant depression. Biological Psychiatry, v. 62, n. 6, p. 686–692, 2007.
RUSSIAN, D. et al. Individual variability in transcranial electric stimulation: modeling the electric field distribution. Brain Stimulation, New York, v. 6, n. 6, p. 804–813, 2013.
STAGG, C. J.; NITSCHE, M. A. Physiological basis of transcranial direct current stimulation. The Neuroscientist, Thousand Oaks, v. 17, n. 1, p. 37–53, 2011.
UK ECT REVIEW GROUP. Efficacy and safety of electroconvulsive therapy in depressive disorders. The Lancet, v. 361, n. 9360, p. 799–808, 2003.
ZAGHI, S.; ARENDT-NIELSEN, L.; FREGNI, F. Mechanisms of action of noninvasive brain stimulation. Brain Stimulation, New York, v. 3, n. 3, p. 163–174, 2010.
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Copyright (c) 2025 Edcleyton de Alencar Ventura, Rodrigo de Souza Lacerda, Samuel Delmondes Guimarães, Vinícius Delmondes de Souza Cruz
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