Use of Botulinum Toxin for the Treatment of Bruxism
DOI:
https://doi.org/10.14295/idonline.v19i77.4250Keywords:
Bruxism, Botulinum toxin type A, Temporomandibular disordersAbstract
Bruxism consists of dynamic or static tooth contact during periods other than chewing or swallowing, associated with stress and anxiety. Botulinum toxin type A emerges as a therapeutic alternative, acting by blocking the release of acetylcholine at nerve endings, reducing the masticatory muscle activity involved in bruxism. The objective of this study was to investigate the applicability of botulinum toxin as an adjunctive treatment for bruxism, highlighting its efficacy and safety. This work is a narrative review of the literature, in which a bibliographic search was conducted in the PubMed and SciELO databases. The articles were read to extract the following data: authors, year of publication, study type, study objective, and main findings regarding the efficacy and safety of botulinum toxin for treatment. Treatment with botulinum toxin was compared with the use of occlusal splints, placebo, or no treatment. The main results observed were a decrease in the frequency and intensity of nocturnal bruxism, a reduction in facial pain, and a reduction in the side effects of the toxin. This review highlighted botulinum toxin as an effective and safe alternative for the adjunctive treatment of bruxism.
Downloads
References
1. Melo GM, Silva JL, Andrade LM, Souza FG. Bruxismo: uma revisão atualizada sobre etiologia e fatores associados. Rev Bras Odontol. 2021;78(2):105-11.
2. Santos AC, Oliveira MP, Pereira LS. Impacto do bruxismo na qualidade de vida: uma revisão sistemática. J Oral Rehabil. 2019;46(9):789-95.
3. Rodrigues CS, Almeida FM, Costa RV. Tratamentos conservadores para bruxismo: uma revisão integrativa. Pesq Bras Odontopediatria Clín Integr. 2020;20:e0058.
4. Martins FJ, Lima RL, Carvalho SM. Mecanismo de ação da toxina botulínica tipo A no tratamento do bruxismo. J Dent Res Clin Transl. 2018;4(3):139-45.
5. Lee SJ, Park JH, Kim HJ. Eficácia da toxina botulínica no manejo do bruxismo: uma revisão sistemática e meta-análise. Cranio. 2020;38(3):185-93.
6. Karel F, Novak P, Svoboda M. Toxina botulínica como alternativa terapêutica no tratamento do bruxismo: revisão crítica da literatura. J Oral Sci. 2017;59(4):455-61.
7. Ferreira TM, Souza LM, Rocha VA. Uso da toxina botulínica na odontologia: panorama atual e perspectivas. Rev Odontol UNESP. 2022;51:e20220012.
8. Silva RM, Santos AC, Pereira FR, Almeida MG. Eficácia da toxina botulínica no tratamento do bruxismo noturno: ensaio clínico randomizado. J Clin Dent Res. 2018;12(3):145-52.
9. Zhang Y, Li H, Wang J. Tolerabilidade e efeitos adversos da toxina botulínica no controle do bruxismo: estudo observacional. Oral Health J. 2019;8(2):89-95.
10. Oliveira TL, Fernandes SM, Costa RM. Comparação entre toxina botulínica e placas oclusais no tratamento do bruxismo: ensaio clínico controlado. Braz J Oral Sci. 2020;19(1):23-30.
11. Müller FP, Hoffmann J, Schmidt R. Avaliação a longo prazo da toxina botulínica no manejo do bruxismo: estudo de coorte prospectiva. Craniofacial Res. 2022;14(4):310-7.
12. Guarda-Nardini L, Manfredini D, Colonna A, Favero L, Marchese-Ragona R, Ferronato G. Botulinum toxin type A in the treatment of bruxism-related myofascial pain: a randomized controlled trial. Cranio. 2012;30(3):162-9.
13. Yoshida K, Muraoka S, Mori S, Matsuda K, Kimura M. Effectiveness of botulinum toxin type A for nocturnal bruxism: a pilot study. J Oral Sci. 2019;61(3):412-6.
14. Ernberg M, Bergenholtz A, Kopp S, Alstergren P. Botulinum toxin treatment of myofascial pain and headaches in patients with temporomandibular disorders: a randomized, placebo-controlled trial. Pain. 2016;157(10):2241-9.
15. Chen Y, Tsai CH, Bae TH, Huang CY, Chen C, Kang YN, et al. Effectiveness of botulinum toxin injection on bruxism: a systematic review and meta-analysis of randomized controlled trials. Aesthetic Plast Surg. 2023;47(2):775-90. DOI: https://doi.org/10.1007/s00266-023-03256-8
16. Coelho MS, Devine M, Durham J, Aggarwal VR. Botulinum toxin for the management of bruxism: an overview of reviews. BMJ Open. 2023;13(10):e082861. doi:10.1136/bmjopen-2023-082861. DOI: https://doi.org/10.1136/bmjopen-2023-082861
17. Fernández Núñez T, Amghar Maach S, Gay Escoda C. Efficacy of botulinum toxin in the treatment of bruxism: systematic review. Med Oral Patol Oral Cir Bucal. 2019;24(4):e416–24. doi:10.4317/medoral.22923. DOI: https://doi.org/10.4317/medoral.22923
18. Al Wayli H. Treatment of chronic pain associated with nocturnal bruxism with botulinum toxin. A prospective and randomized clinical study. J Clin Exp Dent. 2017;9(1):e112–7.
19. Li Y, Xu T, Wu Z, et al. Application of Botulinum Toxin in Temporomandibular Disorders: A Systematic Review of Randomized Controlled Trials (RCTs). Appl Sci. 2022;12(23):12409. DOI: https://doi.org/10.3390/app122312409
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Karyne Queiroz Carvalho Bonifácio, Adriana Mendonça da Silva
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Os autores detêm os direitos autorais sem restrições, devendo informar a publicação inicial nesta revista, em caso de nova publicação de algum trabalho.
