Eficácia do Laser de Baixa Intensidade no Tratamento da Mucosite oral em Pacientes Oncológicos / Efficiency of Low-level Laser in Treatment of Oral Mucositis in Cancer Patients
DOI:
https://doi.org/10.14295/idonline.v14i52.2781Palavras-chave:
Estomatite. Terapia com Luz de Baixa Intensidade. Terapia AntineoplasicaResumo
Resumo: A mucosite oral é definida como uma inflamação da cavidade oral que acomete pacientes submetidos à quimioterapia e/ou radioterapia. Dentre as modalidades terapêuticas empregadas no manejo da referida entidade clínica, o laser de baixa intensidade destaca-se pelo seu potencial de promover analgesia, reduzir a inflamação e estimular a regeneração tecidual. Nessa perspectiva, mostra-se válido caracterizar a eficácia e os benefícios clínicos da utilização deste método terapêutico em pacientes oncológicos acometidos pela mucosite oral. O presente trabalho utilizou-se das bases de dados: Pubmed; Cohrane Library, Lilacs e Scielo e para reunir publicações pertinentes e realizar uma revisão narrativa da literatura sobre a temática em questão. Constatou-se diminuição da morbimortalidade, gravidade da doença, intensidade dos sintomas e melhora na qualidade de vida na utilização do laser de baixa intensidade nos pacientes oncológicos acometidos por mucosite oral.
Downloads
Referências
ALBUQUERQUE, I.L.S., CAMARGO, T.C. Prevenção e tratamento da mucosite oral induzida por radioterapia: revisão de literatura. Rev Bras Cancerol, 53 (2006), pp. 195-209
AL-DASOOQI N, et al. Emerging evidence on the pathobiology of mucositis. Support Care Cancer. 2013;21(11):3233‐3241. doi:10.1007/s00520-013-1900-x
ANTUNES, H. S, et al. Cost-effectiveness of low-level laser therapy (LLLT) in head and neck cancer patients receiving concurrent chemoradiation. 2016. Oral Oncol 52: 85-90
ANTUNES HS, HERCHENHORN D, SMALL IA, et al. Phase III trial of low-level laser therapy to prevent oral mucositis in head and neck cancer patients treated with concurrent chemoradiation. Radiother Oncol. 2013;109(2):297‐302. doi:10.1016/j.radonc.2013.08.010
AMID R, et al. Effect of low level laser therapy on proliferation and differentiation of the cells contributing in bone regeneration. J Lasers Med Sci. 2014;5(4):163‐170.
BJORDAL JM, et al. Low-level laser therapy in acute pain: a systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials. Photomed Laser Surg. 2006;24(2):158–168.
DAUGĖLAITĖ G, et al. Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis. Medicina (Kaunas). 2019;55(2):25.
FRANÇA, C.M., et al. Low-intensity red laser on the prevention and treatment of induced-oral mucositis in hamsters. Photochem Photobiol, 94 (2009), pp. 25-31
GAO, X; XING, D. Molecular mechanisms of cell proliferation induced by low power laser irradiation. J Biomed Sci. 2009;16(1):4.
GINANI F, SOARES D. M, BARRETO M. P, BARBOZA C. A. Effect of low-level laser therapy on mesenchymal stem cell proliferation: a systematic review. Lasers Med Sci. 2015;30(8):2189‐2194. doi:10.1007/s10103-015-1730-9
HAMBLIN, MR et al. Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy. IEEE J Sel Top Quantum Electron. 2016;22(3):7000417. doi:10.1109/JSTQE.2016.2561201
KLUSSMANN, J. P. Head and Neck Cancer - New Insights into a Heterogeneous Disease. Oncol Res Treat. 2017;40(6):318–319.
LALLA, R. V, et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2014;120(10):1453–1461.
LEGOUTÉ, F. et al. Low-level laser therapy in treatment of chemoradiotherapy-induced mucositis in head and neck cancer: results of a randomised, triple blind, multicentre phase III trial. Radiat. Oncol. 2019;14(1):83.
LIM W, KIM J, KIM S, et al. Modulation of lipopolysaccharide-induced NF-κB signaling pathway by 635 nm irradiation via heat shock Hamblin MR. Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation. Photochem Photobiol. 2018;94(2):199‐212. doi:10.1111/php.12864.
MOBADDER M, et al. Photobiomodulation Therapy in the Treatment of Oral Mucositis, Dysphagia, Oral Dryness, Taste Alteration, and Burning Mouth Sensation Due to Cancer Therapy: A Case Series. Int J Environ Res Public Health. 2019;16(22):4505. Published 2019 Nov 15. doi:10.3390/ijerph16224505
OBEROI S, ZAMPERLINI-NETTO G, et al. Effect of prophylactic low level laser therapy on oral mucositis: a systematic review and meta-analysis. PLoS One. 2014;9(9):e107418. Published 2014 Sep 8. doi:10.1371/journal.pone.0107418
OLIVEIRA, C.N. T. Atuação da enfermagem na prevenção e controle da mucosite oral em pacientes submetidos à quimioterapia: uma revisão de literatura. C&D-Revista Eletrônica da Fainor, Vitória da Conquista, v.7, n.1, p.94-107, jan./jun. 2014
OTON-LEITE A. F, CORRÊA DE CASTRO A. C, MORAIS M. O, et al. Effect of intraoral low-level laser therapy on quality of life of patients with head and neck cancer undergoing radiotherapy. Head Neck. 2012;34(3):398‐404. doi:10.1002/hed.21737
PAGLIONI, M. P. et al. Is photobiomodulation therapy effective in reducing pain caused by toxicities related to head and neck cancer treatment? A systematic review. Supportive Care in Cancer, v. 27, n. 11, p. 4043-4054. 2019.
RUSSI, EG, et al. Local and systemic pathogenesis and consequences of regimen-induced inflammatory responses in patients with head and neck cancer receiving chemoradiation. Mediators Inflamm. 2014;2014:518261. doi:10.1155/2014/518261
RUPEL K, et al. Photobiomodulation at Multiple Wavelengths Differentially Modulates Oxidative Stress In Vitro and In Vivo. Oxid Med Cell Longev Hamblin MR. Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation. Photochem Photobiol. 2018;94(2):199‐212. doi:10.1111/php.12864
SANTOS. P, A.C. Messaggi, A. Mantesso, M.H.C.G. Magalhaes. Mucosite oral: perspectivas atuais na prevenção e tratamento. RGO. Rev Gauch Odontol, 57 (2009), p.1
SROUSSI, H. Y. et al. Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis. Cancer Med. 2017;6(12):2918–2931.
SANDOVAL, R.L, et al. Management of chemo and radiotherapy induced oral mucositis with low-energy laser: inicial results of A.C. Camargo Hospital. J Appl Oral Sci, 11 (2003), pp. 337-341
SPERANDIO, F.F, et al. Low-level laser irradiation promotes the proliferation and maturation of keratinocytes during epithelial wound repair. J Biophotonics. 2015;8(10):795‐803. doi:10.1002/jbio.201400064
WORTHINGTON, H.V, et al. Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev. 2011;2011(4):CD000978. Published 2011 Apr 13. doi:10.1002/14651858.CD000978.pub5
ZECHA, J. A, et al. Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations. Support Care Cancer. 2016;24(6):2781–2792.
Downloads
Publicado
Edição
Seção
Licença
Os autores detêm os direitos autorais sem restrições, devendo informar a publicação inicial nesta revista, em caso de nova publicação de algum trabalho.